Serene Scalp Anti-Dandruff Shampoo
Clinical anti-dandruff results, salon-quality formulation.
Serene Scalp Anti-Dandruff Shampoo treats the actual cause of flakes — Malassezia yeast overgrowth and inflammation — with a clinically-active 1% pyrithione zinc complex, in a luxurious Oribe formulation that doesn't sacrifice the way your hair looks, smells or feels. It's the rare medicated shampoo you'll genuinely want to use, with measurable reduction in flaking, itch and scalp irritation from the first wash.
Best For
- Visible flakes, dandruff and seborrheic dermatitis
- Itchy, irritated, or inflamed scalps
- Anyone who hates the way medicated dandruff shampoos make hair feel
- Color-treated and chemically-processed hair with scalp concerns
Key Ingredients
- 1% pyrithione zinc — the FDA-recognized clinical active that controls the Malassezia yeast linked to dandruff and seborrheic dermatitis.
- Salicylic acid (gentle exfoliating dose) — sloughs flake buildup and supports a clearer scalp surface.
- Bisabolol & allantoin — soothe redness and irritation while the active works.
- Bio-Restorative Complex — the antioxidant Oribe signature blend that keeps the hair itself feeling cared-for, not stripped.
Sulfate-, paraben- and sodium-chloride-free. Color-safe, keratin-safe, cruelty-free.
How to Use
- Wet hair and scalp thoroughly.
- Apply directly to the scalp and massage with fingertips for 60 seconds — the pyrithione zinc needs contact time to work.
- Let it sit for 2–3 minutes before rinsing for maximum efficacy.
- Follow with Serene Scalp Balancing Conditioner. Use 2–3× per week for the first 4 weeks, then 1–2× per week to maintain results.
Frequently Asked Questions
How is this different from drugstore dandruff shampoos?
Same clinical-grade active (1% pyrithione zinc), dramatically better formulation: sulfate-free, color-safe, salon-quality conditioning agents, and a scent you'll actually like. Same efficacy, no medicated-shampoo feel.
Is it safe on color-treated hair?
Yes — that's the headline difference. Sulfate-free and sodium-chloride-free, designed to maintain color while it treats the scalp.
How quickly will I see results?
Most users see a meaningful reduction in flaking within 2–3 washes. Full clinical results compound over 4 weeks.
Can I use it every day?
Use 2–3× per week during active flare-ups; reduce to 1–2× per week for maintenance. Daily use isn't necessary and can over-treat the scalp.
Will it dry out my hair?
No — that's the largest difference vs drugstore medicated shampoos. The conditioning base keeps hair soft, even with pyrithione zinc.
Is it safe with keratin treatments?
Yes — sulfate- and sodium-chloride-free, keratin-safe.
Pairs With: Serene Scalp Balancing Conditioner, Serene Scalp Soothing Leave-On Treatment, Serene Scalp Exfoliating Scrub.
- Ships within 2 business days from our salon
- Hand-picked by licensed stylists — every product in stock at the shelf







